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A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery
Full title: | A Handbook for DNA-Encoded Chemistry: Theory and Applications for Exploring Chemical Space and Drug Discovery |
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ISBN: | 9781118487686 |
ISBN 10: | 1118487680 |
Authors: | Goodnow Jr., Robert A. |
Publisher: | Wiley |
Edition: | 1 |
Num. pages: | 480 |
Binding: | Hardcover |
Language: | en |
Published on: | 2014 |
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Synopsis
Just Enough Knowledge? -- A Brief History Of The Development Of Combinatorial Chemistry And The Emerging Need For Dna-encoded Chemistry -- A History Of Dna-encoding -- Dna-compatible Chemistry -- Foundations Of A Dna-encoded Library (del) -- Practices For Synthesizing Dna-encoded Libraries -- Chemical Gene Design For Dna-encoded Libraries -- Analytical Challenges For Dna-encoded Library Systems -- Information Technology: Functionality And Architectures For Dna-encoding -- Theoretical Considerations Of The Application Of Dna-encoded Libraries To Drug Discovery -- Begin With The End In Mind : The Hit-to-lead Process -- Enumeration And Visualization Of Large Combinatorial Chemical Libraries -- Screening Large Compound Collections -- Reported Applications Of Dna-encoded Library Chemistry -- Dual-pharmacophore Dna-encoded Chemical Libraries -- Hit Identification And Hit Follow-up -- Using Dna To Program Chemical Synthesis, Discover New Reactions, And Detect Ligand Binding -- An Outlook And The Changing Feasibility And Economics Of Chemical Diversity Exploration With Dna-encoded Combinatorial Approaches -- Keeping The Promise? An Outlook On Dna Chemical Library Technology. Edited By Robert A. Goodnow, Jr. Includes Bibliographical References And Index.