Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy

Synopsis

Highly Regarded By Both Students And Instructors, Principles Of Pharmacology: The Pathophysiologic Basis Of Drug Therapy, 4th Edition,_offers An Integrated Mechanism-based And Systems-based Approach To Contemporary Pharmacology And Drug Development. An Easy-to-follow Format Helps First- And Second-year Students Grasp Challenging Concepts Quickly And Efficiently. Each Chapter Presents A Clinical Vignette Illustrating A Therapeutic Problem Within A Physiologic Or Biochemical System; Followed By A Discussion Of The Biochemistry, Physiology, And Pathophysiology Of The System; And Concluding With A Presentation Of The Pharmacology Of_the Drugs And Drug Classes That Activate Or Inhibit The System By Interacting With Specific Molecular And Cellular Targets. Chapters Are Integrated Into Sections That Focus On Organ Systems And Therapeutic Areas Of Highest Importance. Clear, Concise Illustrations Highlight Key Points, And Drug Summary Tables Offer Quick Access To Essential Information--publisher's Description. Machine Generated Contents Note: Section I Fundamental Principles Of Pharmacology -- 1. Drug -- Receptor Interactions / David E. Golan -- 2. Pharmacodynamics / David E. Golan -- 3. Pharmacokinetics / David E. Golan -- 4. Drug Metabolism / F. Peter Guengerich -- 5. Drug Transporters / Keith A. Hoffmaster -- 6. Drug Toxicity / David E. Golan -- 7. Pharmacogenomics / Kelan Tantisira -- Section Ii Principles Of Neuropharmacology -- Section Iia Fundamental Principles Of Neuropharmacology -- 8. Principles Of Cellular Excitability And Electrochemical Transmission / Gary R. Strichartz -- 9. Principles Of Nervous System Physiology And Pharmacology / Daniel H. Lowenstein -- Section Iib Principles Of Autonomic And Peripheral Nervous System Pharmacology -- 10. Cholinergic Pharmacology / Gary R. Strichartz -- 11. Adrenergic Pharmacology / David E. Golan -- 12. Local Anesthetic Pharmacology / Gary R. Strichartz -- Section Iic Principles Of Central Nervous System Pharmacology -- 13. Pharmacology Of Gabaergic And Glutamatergic Neurotransmission / Eng H. Lo -- 14. Pharmacology Of Dopaminergic Neurotransmission / Victor W. Sung -- 15. Pharmacology Of Serotonergic And Central Adrenergic Neurotransmission / Roy H. Perlis -- 16. Pharmacology Of Abnormal Electrical Neurotransmission In The Central Nervous System / Daniel H. Lowenstein -- 17. General Anesthetic Pharmacology / Keith W. Miller -- 18. Pharmacology Of Analgesia / Clifford J. Woolf -- 19. Pharmacology Of Drugs Of Abuse / Sachin Patel -- Section Iii Principles Of Cardiovascular Pharmacology -- 20. Pharmacology Of Cholesterol And Lipoprotein Metabolism / David E. Cohen -- 21. Pharmacology Of Volume Regulation / Seth L. Alper -- 22. Pharmacology Of Vascular Tone / Joseph Loscalzo -- 23. Pharmacology Of Hemostasis And Thrombosis / David E. Golan -- 24. Pharmacology Of Cardiac Rhythm / David E. Clapham -- 25. Pharmacology Of Cardiac Contractility / Ehrin J. Armstrong -- 26. Integrative Cardiovascular Pharmacology: Hypertension, Ischemic Heart Disease, And Heart Failure / Ehrin J. Armstrong -- Section Iv Principles Of Endocrine Pharmacology -- 27. Pharmacology Of The Hypothalamus And Pituitary Gland / Ursula B. Kaiser -- 28. Pharmacology Of The Thyroid Gland / William W. Chin -- 29. Pharmacology Of The Adrenal Cortex / Gail K. Adler -- 30. Pharmacology Of Reproduction / Robert L. Barbieri -- 31. Pharmacology Of The Endocrine Pancreas And Glucose Homeostasis / Steven E. Shoelson -- 32. Pharmacology Of Bone Mineral Homeostasis / Ehrin J. Armstrong -- Section V Principles Of Chemotherapy -- 33. Principles Of Antimicrobial And Antineoplastic Pharmacology / David E. Golan -- 34. Pharmacology Of Bacterial Infections: Dna Replication, Transcription, And Translation / Donald M. Coen -- 35. Pharmacology Of Bacterial And Mycobacterial Infections: Cell Wall Synthesis / Sarah P. Hammond -- 36. Pharmacology Of Fungal Infections / April W. Armstrong -- 37. Pharmacology Of Parasitic Infections / Edward T. Ryan -- 38. Pharmacology Of Viral Infections / Donald M. Coen -- 39. Pharmacology Of Cancer: Genome Synthesis, Stability, And Maintenance / David A. Frank -- 40. Pharmacology Of Cancer: Signal Transduction / David A. Frank -- 41. Principles Of Combination Chemotherapy / David E. Golan -- Section Vi Principles Of Inflammation And Immune Pharmacology -- 42. Principles Of Inflammation And The Immune System / April W. Armstrong -- 43. Pharmacology Of Eicosanoids / Charles N. Serhan -- 44. Histamine Pharmacology / April W. Armstrong -- 45. Pharmacology Of Hematopoiesis And Immunomodulation / George D. Demetri -- 46. Pharmacology Of Immunosuppression / April W. Armstrong -- 47. Integrative Inflammation Pharmacology: Peptic Ulcer Disease / Helen M. Shields -- 48. Integrative Inflammation Pharmacology: Asthma / Stephen Lazarus -- 49. Integrative Inflammation Pharmacology: Gout / Lloyd B. Klickstein -- Section Vii Environmental Toxicology -- 50. Environmental Toxicology / Joshua M. Galanter -- Section Viii Fundamentals Of Drug Development And Regulation -- 51. Drug Discovery And Preclinical Development / Maarten Postema -- 52. Clinical Drug Evaluation And Regulatory Approval / Alexander E. Kuta -- 53. Systematic Detection Of Adverse Drug Events / Jerry Avorn -- Section Ix Frontiers In Pharmacology -- 54. Protein Therapeutics / David E. Golan -- 55. Drug Delivery Modalities / Robert Langer. David E. Golan, Editor In Chief ; Ehrin J. Armstrong, April W. Armstrong, Associate Editors. Includes Bibliographical References And Index.