Cardiovascular Diseases: Genetic Susceptibility, Environmental Factors and their Interaction

Synopsis

Front Cover; Cardiovascular Diseases; Cardiovascular Diseases: Genetic Susceptibility, Environmental Factors And Their Interaction; Copyright; Dedication; Contents; List Of Contributors; Acknowledgments; 1 -- Summary ; 2 -- Atherosclerosis And Coronary Artery Disease: From Basics To Genetics ; Introduction; Normal Artery Structures; Pathogenesis Of Atherosclerosis; Initiation Of Atheroma; The Role Of Endothelium; The Role Of Ldl Particles; The Role Of Inflammation; Monocyte-derived Macrophages; Ldl And Inflammation; Atheroprotective Mechanisms And Inflammation; Retention Of Macrophages T Lymphocytesthe Formation Of Atherosclerotic Plaque; Apoptosis And Efferocytosis Of Macrophages; The Role Of Vascular Smooth Muscle Cells; Neovascularization; Clinical Implications Of Atherosclerosis; Genetics Of Coronary Artery Disease; Abo Blood Groups; Lipid-associated Genes; Other Atherosclerosis-related Genes; The Role Of Micrornas; Atherosclerosis: Therapeutic Options; References; 3 -- The Role Of Genetics In Acute Coronary Syndrome ; Introduction; Clopidogrel; Metabolism And Pharmacokinetics; Absorption And Role Of P-glycoprotein; Hepatic Carboxylation And Oxidation Effect Of Genotypic Polymorphismsabcb1; Cyp2c19; Nomenclature; Cyp2c19*2 And Other Loss-of-function Alleles; Pharmacokinetics/pharmacodynamics; Clinical Trials And Meta-analyses; Cyp2c19*17 Gain Of Function Allele; Incidence Of Cyp2c19 Alleles In Specific Ethnic Groups; Cyp3a4; Cyp1a2; Paraoxonase 1; Cyp4f2; Platelet Surface Receptors; P2y12 Receptor; Platelet Endothelial Aggregation Receptor-1; Protease Activated Receptors; Nongenetic Factors; Clopidogrel And Proton Pump Inhibitors; Prasugrel; Metabolism; Pharmacokinetics, Pharmacodynamics, And Clinical Trials; Ticagrelor; Metabolism Pharmacokinetics, Pharmacodynamics, And Clinical Trialscompliance; Drug-drug Interactions; Genotyping Assays; Cost-effectiveness Of Genotyping; Genetic Polymorphisms Related To Aspirin; Future Directions; Cilostazol And Role Of Genetics; Statins And The Role Of Genetics; Summary: Role Of Genotyping In Acute Coronary Syndrome; References; 4 -- Global Epidemiology And Incidence Of Cardiovascular Disease ; Introduction; Global Burden Of Disease: Reporting Metrics; Measuring The Global Burden Of Cardiovascular Disease; Limitations Of The Quality And Completeness Of Data Changes In Total Disease Burden Versus Cvdglobal Cardiovascular Mortality; Global Cvd Mortality Rates By Who Region; Global Cvd Mortality Rates By Who/world Bank Region; Age And Gender Global Cvd Mortality Rates; Global Cardiovascular Daly; Global Cvd Lost Dalys Within Who Regions; Global Cvd Lost Dalys By Who/world Bank Region; Age And Gender Global Cvd Loss Of Dalys; Risk Factors For Cvd Globally; Hypertension; Diabetes Mellitus; Tobacco; Dyslipidemia; Physical Activity; Alcohol Consumption; Epidemiological Transition; Aging Population; Ethnicity; European; Chinese; South Asian; Hispanic Edited By Nikolaos Papageorgiou. Mode Of Access: World Wide Web.